In vitro activity of amphotericin B and itraconazole in combination with flucytosine, sulfadiazine and quinolones against Exophiala spinifera

J Antimicrob Chemother. 2003 May;51(5):1297-300. doi: 10.1093/jac/dkg218. Epub 2003 Apr 14.

Abstract

The combined effects of antifungal and antibiotic drugs against Exophiala spinifera were evaluated in vitro by the chequer-board method, calculated as a fractional inhibitory concentration (FIC) index. Amphotericin B was combined with flucytosine and ciprofloxacin, whereas itraconazole was combined with ciprofloxacin, levofloxacin, lomefloxacin and sulfadiazine. Synergic effects were observed for the combinations of itraconazole with ciprofloxacin and levofloxacin, and amphotericin B with ciprofloxacin and flucytosine. No antagonism was observed for any combination tested.

MeSH terms

  • Amphotericin B / pharmacology*
  • Anti-Infective Agents / pharmacology*
  • Antifungal Agents / pharmacology*
  • Drug Combinations
  • Exophiala / drug effects*
  • Flucytosine / pharmacology*
  • Itraconazole / pharmacology*
  • Microbial Sensitivity Tests
  • Quinolones / pharmacology*
  • Sulfadiazine / pharmacology*

Substances

  • Anti-Infective Agents
  • Antifungal Agents
  • Drug Combinations
  • Quinolones
  • Sulfadiazine
  • Itraconazole
  • Amphotericin B
  • Flucytosine