TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation

Dev Dyn. 2003 May;227(1):48-55. doi: 10.1002/dvdy.10287.

Abstract

The Hox genes are a family of homeodomain-containing transcription factors that determine anteroposterior identity early on in development. Although much is now known about their regulation and function, very little is known of their effector (downstream target) genes. Here, we show that the TALE class homeodomain transcription factor Irx5 is a direct, positively regulated target of Hoxb4.

MeSH terms

  • Animals
  • Cycloheximide / pharmacology
  • Dexamethasone / pharmacology
  • Embryo, Nonmammalian / anatomy & histology
  • Embryo, Nonmammalian / drug effects
  • Embryo, Nonmammalian / physiology
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental*
  • Glucocorticoids / pharmacology
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / metabolism*
  • In Situ Hybridization
  • Protein Synthesis Inhibitors / pharmacology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism*
  • Transcription, Genetic*
  • Up-Regulation
  • Xenopus laevis

Substances

  • Glucocorticoids
  • Homeodomain Proteins
  • Protein Synthesis Inhibitors
  • Transcription Factors
  • Dexamethasone
  • Cycloheximide