New acetylenic acids from a sponge of the genus Stelletta

J Nat Prod. 2003 Apr;66(4):566-8. doi: 10.1021/np020345q.

Abstract

Three new acetylenic metabolites (1-3) were isolated from the sponge Stelletta sp. collected from Gagu-Do, Korea. On the basis of the results of combined spectroscopic analyses, the structures of these compounds were determined to be an acetylenic acid, its 2-methoxy analogue, and corresponding anhydride, respectively. The new compounds exhibited weak cytotoxicity against a human leukemia cell-line (K562).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Fatty Acids, Unsaturated / chemistry
  • Fatty Acids, Unsaturated / isolation & purification*
  • Fatty Acids, Unsaturated / pharmacology
  • Humans
  • Korea
  • Leukemia
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Tumor Cells, Cultured / drug effects

Substances

  • Alkynes
  • Antineoplastic Agents
  • Fatty Acids, Unsaturated
  • 2-hexadecynoic acid