Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus

Bioorg Med Chem Lett. 2003 May 19;13(10):1821-4. doi: 10.1016/s0960-894x(03)00262-2.

Abstract

A series of highly potent HIV protease inhibitors have been designed and synthesized. These compounds are active against various clinical viral isolates as well as wild-type virus. The synthesis and biological activity of these HIV protease inhibitors are discussed.

MeSH terms

  • Amines
  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / pharmacology
  • Cell Line
  • Drug Design
  • HIV Protease Inhibitors / chemical synthesis*
  • HIV Protease Inhibitors / pharmacology
  • Heterocyclic Compounds
  • Humans
  • Inhibitory Concentration 50
  • Mutation
  • Oligopeptides / chemical synthesis
  • Oligopeptides / pharmacology
  • Structure-Activity Relationship
  • Virus Replication / drug effects

Substances

  • Amines
  • Anti-HIV Agents
  • HIV Protease Inhibitors
  • Heterocyclic Compounds
  • Oligopeptides