Does the right hemisphere take over after damage to Broca's area? the Barlow case of 1877 and its history

Brain Lang. 2003 Jun;85(3):385-95. doi: 10.1016/s0093-934x(03)00060-9.

Abstract

In 1877 Thomas Barlow, a London physician, published a remarkable case of functional recovery of speech following brain damage. It involved a 10-year-old boy who had lost his speech, regained it, and lost it again before he died from a disorder that affected his heart and produced embolisms that subsequently affected other organs, including his brain. Examination of the boy's brain revealed two focal regions of softening; one that affected Broca's area and the left facial-motor area, and another, which occurred weeks later, in the homologous regions of the right hemisphere. Although Barlow was most concerned with motor deficits, others at the turn of the century began to cite this case as strong evidence that the corresponding region of the right hemisphere can take over speech functions for Broca's area on the left. Whether this case really provides good support for functional takeover or vicariation theory is critically evaluated in the light of contemporary research, including PET scan studies involving damage to Broca's speech region.

Publication types

  • Biography
  • Historical Article
  • Portrait
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aphasia, Broca / history*
  • Aphasia, Broca / physiopathology
  • Child
  • England
  • Frontal Lobe / blood supply
  • Frontal Lobe / physiopathology*
  • Functional Laterality / physiology*
  • History, 19th Century
  • History, 20th Century
  • Humans
  • Male
  • Neural Pathways / physiology

Personal name as subject

  • Thomas Barlow