Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

J Martel-Pelletier; D Lajeunesse; P Reboul; J-P Pelletier

doi:10.1136/ard.62.6.501

Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

Ann Rheum Dis. 2003 Jun;62(6):501-9. doi: 10.1136/ard.62.6.501.

Authors

J Martel-Pelletier¹, D Lajeunesse, P Reboul, J-P Pelletier

Affiliation

¹ Osteoarthritis Research Unit, Centre hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Québec H2L 4M1 Canada. jm@martelpelletier.ca

Abstract

Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin formation. Such combined inhibition avoids some of the disadvantages of selective COX-2 inhibitors and spares the gatrointestinal mucosa.

Publication types

Review

MeSH terms

Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Cyclooxygenase Inhibitors / therapeutic use*
Drug Synergism
Humans
Inflammation / drug therapy
Inflammation / physiopathology
Leukotrienes / physiology
Lipoxygenase Inhibitors* / therapeutic use*
Prostaglandin-Endoperoxide Synthases / physiology

Substances

Anti-Inflammatory Agents, Non-Steroidal
Cyclooxygenase Inhibitors
Leukotrienes
Lipoxygenase Inhibitors
Prostaglandin-Endoperoxide Synthases