Abstract
This is the first report of fMRI in monozygotic twins discordant for AD. FMRI brain activation patterns were examined during visuospatial and verbal working memory tasks. The affected twin had greater parietal involvement bilaterally during both working memory tasks and reduced left dorsolateral prefrontal cortex activity on the visuospatial memory task. Thus, fMRI may identify additional brain regions recruited in patients with AD to perform a given cognitive task.
MeSH terms
-
Aged
-
Alzheimer Disease / diagnostic imaging
-
Alzheimer Disease / genetics
-
Alzheimer Disease / pathology*
-
Apolipoprotein E4
-
Apolipoproteins E / genetics
-
Brain Mapping
-
Cerebral Cortex / diagnostic imaging
-
Cerebral Cortex / pathology*
-
Cerebral Cortex / physiopathology
-
Diseases in Twins*
-
Homozygote
-
Humans
-
Magnetic Resonance Imaging*
-
Male
-
Memory Disorders / genetics
-
Memory Disorders / pathology
-
Neuropsychological Tests
-
Parietal Lobe / diagnostic imaging
-
Parietal Lobe / pathology
-
Parietal Lobe / physiopathology
-
Radionuclide Imaging
-
Single-Blind Method
-
Subtraction Technique
-
Twins, Monozygotic*
-
Verbal Learning
Substances
-
Apolipoprotein E4
-
Apolipoproteins E