[Livedo-like dermatitis (Nicolau's syndrome) after injection of Copolymer-1 (Glatiramer acetate)]

Rev Neurol (Paris). 2003 May;159(5 Pt 1):571-3.
[Article in French]

Abstract

We report the first case of a 33-year-old woman with multiple sclerosis, who developed a livedo-like dermatitis after injection of Copolymere-1. This disease is characterized by the development of acute violent pain during or immediately after injection, and a livedo-like plaque followed by necrosis corresponding to an arterial ischemia by vasospasm or thrombosis. Early treatment with vasoactive and anticoagulation agents is required. Surgery may be necessary.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Acute Disease
  • Adult
  • Anticoagulants / therapeutic use
  • Arm / blood supply
  • Brachial Artery / pathology
  • Drug Eruptions / drug therapy
  • Drug Eruptions / etiology*
  • Female
  • Glatiramer Acetate
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / adverse effects*
  • Injections, Intra-Arterial
  • Ischemia / chemically induced
  • Multiple Sclerosis / drug therapy
  • Necrosis
  • Pain / chemically induced
  • Peptides / administration & dosage
  • Peptides / adverse effects*
  • Syndrome

Substances

  • Anticoagulants
  • Immunosuppressive Agents
  • Peptides
  • Glatiramer Acetate