Abstract
Three new endocannabinoid analogues in which amide moiety was replaced either by oxomethylene group or ester moiety with simultaneous substitution of both alpha-hydrogens with methyl groups were synthesized and their abilities to interact with CB1-receptor and FAAH were investigated.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amidohydrolases / antagonists & inhibitors
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Animals
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Arachidonic Acids / pharmacology
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Binding, Competitive
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Cannabinoid Receptor Modulators / chemical synthesis*
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Cannabinoid Receptor Modulators / chemistry
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Cannabinoid Receptor Modulators / pharmacology*
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Endocannabinoids*
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Ethylene Glycols / pharmacology
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Polyunsaturated Alkamides
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Radioligand Assay
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Rats
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Receptor, Cannabinoid, CB1 / metabolism
Substances
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Arachidonic Acids
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Cannabinoid Receptor Modulators
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Endocannabinoids
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Enzyme Inhibitors
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Ethylene Glycols
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Polyunsaturated Alkamides
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Receptor, Cannabinoid, CB1
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arachidonoylethylene glycol
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Amidohydrolases
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fatty-acid amide hydrolase
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anandamide