Synthesis of a functionalized high affinity mannose receptor ligand and its application in the construction of peptide-, polyamide- and PNA-conjugates

J Pept Sci. 2003 Jun;9(6):375-85. doi: 10.1002/psc.463.

Abstract

The synthesis of a high affinity mannose receptor ligand, appropriately functionalized for chemoselective ligation with an antigen or DNA-binding moieties is described. By a combination of solid- and solution-phase chemistry a versatile synthesis of the target structure was accomplished. Examples of subsequent ligation reactions are described.

MeSH terms

  • Amino Acid Sequence
  • Binding, Competitive
  • Chromatography, High Pressure Liquid
  • DNA / metabolism
  • Lectins, C-Type / metabolism*
  • Ligands*
  • Mannose Receptor
  • Mannose-Binding Lectins / metabolism*
  • Models, Chemical
  • Molecular Sequence Data
  • Molecular Structure
  • Nylons / chemical synthesis
  • Nylons / chemistry
  • Nylons / metabolism
  • Oligopeptides / chemical synthesis
  • Oligopeptides / chemistry
  • Oligopeptides / metabolism
  • Peptide Nucleic Acids / chemical synthesis
  • Peptide Nucleic Acids / chemistry
  • Peptide Nucleic Acids / metabolism
  • Receptors, Cell Surface / metabolism*
  • Time Factors

Substances

  • Lectins, C-Type
  • Ligands
  • Mannose Receptor
  • Mannose-Binding Lectins
  • Nylons
  • Oligopeptides
  • Peptide Nucleic Acids
  • Receptors, Cell Surface
  • DNA