Abstract
A series of derivatives of the new ring system pyrrolo[2,3-h]quinoline-2-one was synthesized and evaluated as photoreagents toward cultured human tumor cells. Remarkable phototoxycity resulted for some derivatives, especially those bearing the phenyl group at the 7-position.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Fibrosarcoma
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Humans
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Photochemotherapy
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Photosensitizing Agents / chemical synthesis*
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Photosensitizing Agents / pharmacology
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Pyrroles / chemistry*
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Quinolones / chemical synthesis*
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Quinolones / pharmacology
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Photosensitizing Agents
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Pyrroles
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Quinolones