This study is aimed at assessing the outcomes of home care treatment for people living with AIDS in Mozambique. The authors have analysed data from 62 adult patients undergoing a Home Care Program carried out by the Sant'Egidio Community, Italy and the Sue Ryder Care in Matola, Mozambique. The above-mentioned program complies with the WHO guidelines and provides for free antiretroviral therapies and laboratory exams. After hardly two-year treatment, the mortality rate of the sub-sample examined dropped by nearly 80%. Both compliance and adverse reactions have shown to be similar to the reported levels in developed countries. This program is unprecedented in Mozambique and has proved extremely effective for the affected population.