High cell density cultivation of Brevibacterium linens and formation of proteinases and lipase

Biotechnol Lett. 2003 May;25(9):705-8. doi: 10.1023/a:1023402529882.

Abstract

Brevibacterium linens forms hydrolytic enzymes which can be used to accelerate the ripening of cheese without causing bitterness. B. linens ATCC 9172 was grown to a high cell density (50 g dry wt l-1 after 60 h) in a mineral medium containing lactic acid, soy-peptone and ammonium sulphate by applying a continuous feed of nutrients. The maximal activities of L-leucine aminopeptidase and cell-associated proteinase were 286 U l-1 and 202 U l-1, respectively. The cell-associated lipolytic activity exhibited a strong and sudden increase at 46 h, resulting in a maximum of 9.5 U g-1 dry wt; thus the volumetric productivity of proteolytic and lipolytic activity was 4220 U l-1 h-1 and 7.3 U l-1 h-1, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ammonium Sulfate / pharmacology
  • Brevibacterium / classification
  • Brevibacterium / drug effects
  • Brevibacterium / enzymology*
  • Brevibacterium / growth & development*
  • Cell Count
  • Cell Culture Techniques / methods*
  • Cells, Cultured
  • Culture Media / pharmacology
  • Endopeptidases / biosynthesis
  • Enzyme Activation
  • Lactic Acid / pharmacology
  • Leucyl Aminopeptidase / biosynthesis
  • Lipase / biosynthesis*
  • Peptones / pharmacology
  • Quality Control
  • Soybean Proteins / pharmacology
  • Species Specificity

Substances

  • Culture Media
  • Peptones
  • Soybean Proteins
  • Lactic Acid
  • Lipase
  • Endopeptidases
  • Leucyl Aminopeptidase
  • Ammonium Sulfate