Answers and questions from the KvAP structures

Neuron. 2003 Jul 31;39(3):395-400. doi: 10.1016/s0896-6273(03)00472-0.

Abstract

The recent landmark structures of KvAP, a voltage-gated potassium (Kv) channel, provide the first high-resolution experimental structural models of this class of proteins. Previous extensive studies of Kv channels provide a means to evaluate and interpret the KvAP structures. In this minireview, we survey different experimental approaches to Kv channels and map these findings to KvAP, showing that the relationship between the KvAP structures and other Kv channels is uncertain.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Ion Channel Gating / physiology*
  • Mutation
  • Potassium Channels, Voltage-Gated / chemistry*
  • Potassium Channels, Voltage-Gated / physiology*
  • Structure-Activity Relationship

Substances

  • Potassium Channels, Voltage-Gated