The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ

Peter T Simpson; Theodora Gale; Laura G Fulford; Jorge S Reis-Filho; Sunil R Lakhani

doi:10.1186/bcr624

The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ

Breast Cancer Res. 2003;5(5):258-62. doi: 10.1186/bcr624. Epub 2003 Jul 29.

Authors

Peter T Simpson¹, Theodora Gale, Laura G Fulford, Jorge S Reis-Filho, Sunil R Lakhani

Affiliation

¹ The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

PMID: 12927036
PMCID: PMC314428
DOI: 10.1186/bcr624

Abstract

The term lobular neoplasia refers to a spectrum of lesions featuring atypical lobular hyperplasia and lobular carcinoma in situ (LCIS). The histopathological characteristics of these lesions are well documented. What is less well understood is the management implications of a patient diagnosed with LCIS; treatment regimes vary and are somewhat controversial. LCIS is now considered a risk factor and a non-obligate precursor for the subsequent development of invasive cancer.

Publication types

Review

MeSH terms

Breast Neoplasms / classification
Breast Neoplasms / diagnosis*
Breast Neoplasms / pathology*
Breast Neoplasms / therapy
Carcinoma in Situ / diagnosis*
Carcinoma in Situ / pathology*
Carcinoma in Situ / therapy
Carcinoma, Lobular / diagnosis*
Carcinoma, Lobular / pathology*
Carcinoma, Lobular / therapy
Diagnosis, Differential
Female
Humans
Hyperplasia
Neoplasm Invasiveness
Precancerous Conditions / diagnosis*
Precancerous Conditions / pathology*
Precancerous Conditions / therapy