Abstract
Bone marrow cells have been suggested to have multilineage plasticity including formation of cardiac tissue. We have established a cardiomyogenic (CMG) cell line from mouse bone marrow stromal cells that can be induced to differentiate into cardiomyocytes in vitro by 5-azacytidine treatment. A number of lines of evidence confirm the cardiomyocyte characteristics of CMG cells.
MeSH terms
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Action Potentials
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Adult
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Azacitidine / pharmacology
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Bone Marrow Cells
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Cell Culture Techniques / methods
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Cell Differentiation / drug effects
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Cell Line*
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Humans
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Mesenchymal Stem Cells / cytology*
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Muscle Fibers, Skeletal / ultrastructure
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Myocytes, Cardiac / chemistry
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Myocytes, Cardiac / cytology*
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Myocytes, Cardiac / physiology
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Proteins / analysis
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Regeneration*
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Secretory Vesicles
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Stromal Cells / cytology