Use of adult marrow mesenchymal stem cells for regeneration of cardiomyocytes

Bone Marrow Transplant. 2003 Aug:32 Suppl 1:S25-7. doi: 10.1038/sj.bmt.1703940.

Abstract

Bone marrow cells have been suggested to have multilineage plasticity including formation of cardiac tissue. We have established a cardiomyogenic (CMG) cell line from mouse bone marrow stromal cells that can be induced to differentiate into cardiomyocytes in vitro by 5-azacytidine treatment. A number of lines of evidence confirm the cardiomyocyte characteristics of CMG cells.

MeSH terms

  • Action Potentials
  • Adult
  • Azacitidine / pharmacology
  • Bone Marrow Cells
  • Cell Culture Techniques / methods
  • Cell Differentiation / drug effects
  • Cell Line*
  • Humans
  • Mesenchymal Stem Cells / cytology*
  • Muscle Fibers, Skeletal / ultrastructure
  • Myocytes, Cardiac / chemistry
  • Myocytes, Cardiac / cytology*
  • Myocytes, Cardiac / physiology
  • Proteins / analysis
  • Regeneration*
  • Secretory Vesicles
  • Stromal Cells / cytology

Substances

  • Proteins
  • Azacitidine