Viral therapy for glioblastoma

Cancer J. 2003 May-Jun;9(3):167-79. doi: 10.1097/00130404-200305000-00005.

Abstract

Malignant gliomas remain amongst the most difficult cancer to treat. Viral-based gene therapies have been employed for the last decade in preclinical and clinical modes as a novel treatment modality. In this review, such therapies are summarized. The overwhelming majority of clinical studies point one to conclude that methodologies that will increase tumor infection/transduction will lead to enhanced therapeutic results.

Publication types

  • Review

MeSH terms

  • Adenoviridae
  • Antineoplastic Agents / therapeutic use
  • Antiviral Agents / therapeutic use
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / therapy*
  • Clinical Trials as Topic
  • Cyclophosphamide / therapeutic use
  • Dependovirus
  • Flucytosine / therapeutic use
  • Ganciclovir / therapeutic use
  • Genetic Therapy / methods*
  • Genetic Vectors*
  • Glioblastoma / genetics*
  • Glioblastoma / therapy*
  • Herpesviridae
  • Humans
  • Mammalian orthoreovirus 3
  • Retroviridae
  • Transgenes / drug effects*

Substances

  • Antineoplastic Agents
  • Antiviral Agents
  • Cyclophosphamide
  • Flucytosine
  • Ganciclovir