The viral potassium channel Kcv: structural and functional features

FEBS Lett. 2003 Sep 18;552(1):12-6. doi: 10.1016/s0014-5793(03)00777-4.

Abstract

The chlorella virus PBCV-1 was the first virus found to encode a functional potassium channel protein (Kcv). Kcv is small (94 aa) and basically consists of the M1-P-M2 (membrane-pore-membrane) module typical of the pore regions of all known potassium channels. Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Barium / pharmacology
  • Biophysical Phenomena
  • Biophysics
  • CHO Cells
  • Cricetinae
  • DNA Ligases / metabolism
  • DNA Ligases / physiology
  • Kinetics
  • Models, Molecular
  • Molecular Sequence Data
  • Phycodnaviridae / metabolism*
  • Potassium / chemistry
  • Potassium / metabolism
  • Potassium Channels / chemistry*
  • Potassium Channels / physiology*
  • Protein Structure, Tertiary
  • RNA, Complementary / metabolism
  • Sequence Homology, Amino Acid
  • Viral Proteins*
  • Xenopus laevis

Substances

  • Kcv potassium channel, Chlorella virus
  • Potassium Channels
  • RNA, Complementary
  • Viral Proteins
  • Barium
  • Chlorella virus DNA ligase
  • DNA Ligases
  • Potassium