The effect of thymic hormones (TFX) on lymphocyte subpopulations and proliferation after maximal physical effort

Arch Immunol Ther Exp (Warsz). 1992;40(2):157-62.

Abstract

The studies were performed on healthy well-trained cyclists. Maximal physical exercise was performed on a Monark bicycle ergometer according to individual schemes. Heart rate amounting to about 200 bts/min and oxygen consumption stabilization were considered as criteria for maximal physical exercise. In this study we have investigated the effect of short-term stimulation of conditioned sportsmen with thymic hormones and evaluated T cell subsets, DR antigen and transferrin receptor expression as well as mitogen-induced proliferation of lymphocytes before and after maximal physical effort. The results suggest that intensive physical exercise may be responsible for transient decrease of CD4/CD8 ratio and mitogen responsiveness, and increase of mononuclear cells number bearing HLA DR+ and CD71 antigens. These changes were modified by the treatment with thymic hormones.

MeSH terms

  • Adult
  • Antigens, CD / analysis
  • Exercise Test
  • HLA-DR Antigens / analysis
  • Humans
  • Immunophenotyping
  • Lymphocyte Activation / drug effects
  • Lymphocyte Activation / physiology*
  • Lymphocyte Culture Test, Mixed
  • Lymphocyte Subsets / drug effects
  • Lymphocyte Subsets / immunology*
  • Male
  • Physical Exertion*
  • Thymus Hormones / pharmacology
  • Thymus Hormones / physiology*

Substances

  • Antigens, CD
  • HLA-DR Antigens
  • Thymus Hormones