Pyrogenic action of endothelin in conscious rabbit

Biochem Biophys Res Commun. 1992 Aug 14;186(3):1322-6. doi: 10.1016/s0006-291x(05)81550-5.

Abstract

Injection of 0.3 nmol/kg endothelin(ET)-1 into the ear vein of conscious rabbits induced a significant increase in body temperature. ETB receptor specific agonist, namely 4-Ala-ET-1, also caused an elevation of the body temperature in a dose-dependent manner by injection into the ear vein of rabbit. These results suggest that ET play important roles in regulation of body temperature through selective stimulation of ETB receptor.

MeSH terms

  • Analysis of Variance
  • Animals
  • Body Temperature / drug effects*
  • Endothelins / administration & dosage
  • Endothelins / pharmacology*
  • Indomethacin / pharmacology
  • Injections, Intravenous
  • Male
  • Pyrogens / administration & dosage
  • Pyrogens / pharmacology*
  • Rabbits
  • Receptors, Cell Surface / drug effects
  • Receptors, Cell Surface / physiology
  • Receptors, Endothelin
  • Reference Values
  • Time Factors

Substances

  • Endothelins
  • Pyrogens
  • Receptors, Cell Surface
  • Receptors, Endothelin
  • endothelin 1, Ala(1,3,11,15)-
  • Indomethacin