Characterization of a new tissue-specific transcription factor binding to the simian virus 40 enhancer TC-II (NF-kappa B) element

Mol Cell Biol. 1992 Nov;12(11):5217-27. doi: 10.1128/mcb.12.11.5217-5227.1992.

Abstract

We have biochemically and functionally characterized a new transcription factor, NP-TCII, which is present in nuclei from unstimulated T and B lymphocytes but is not found in nonhematopoietic cells. This factor has a DNA-binding specificity similar to that of NF-kappa B but is unrelated to this or other Rel proteins by functional and biochemical criteria. It can also be distinguished from other previously described lymphocyte-specific DNA-binding proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Binding Sites
  • Cell Differentiation / genetics
  • Chromatography, Gel
  • Consensus Sequence
  • DNA
  • Enhancer Elements, Genetic*
  • Humans
  • Lymphocytes / metabolism
  • Molecular Sequence Data
  • NF-kappa B / genetics*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-rel
  • Simian virus 40 / genetics*
  • Transcription Factors / metabolism*

Substances

  • NF-kappa B
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-rel
  • Transcription Factors
  • DNA