[The neurochemical mechanisms underlying possible recurrences of alcoholism]

Eksp Klin Farmakol. 1992 May-Jun;55(3):67-70.
[Article in Russian]

Abstract

Experiments on chronic alcoholized rats revealed the similar changes in brain dopamine receptors, in brain and blood catecholamines as well as in blood cyclic adenosine monophosphate during both short- and long-term alcohol deprivation. It is concluded that such changes may form material basis for alcoholism relapses.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Alcoholism / metabolism*
  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Brain Chemistry / drug effects
  • Catecholamines / analysis
  • Catecholamines / metabolism
  • Corpus Striatum / chemistry
  • Cyclic AMP / blood
  • Ethanol / adverse effects
  • Hippocampus / chemistry
  • Male
  • Mesencephalon / chemistry
  • Rats
  • Receptors, Dopamine / analysis
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / metabolism
  • Recurrence
  • Substance Withdrawal Syndrome / metabolism

Substances

  • Catecholamines
  • Receptors, Dopamine
  • Ethanol
  • Cyclic AMP