Abstract
We have examined mixed populations and cloned murine CD4+ T cell lines for their sensitivity to anti-CD3-stimulated suicide. The sensitivity of CD4+ clones to anti-CD3-stimulated suicide is independent of their interleukin-2/interleukin-4 or interferon-gamma secretion profile or their lytic efficiency in anti-CD3 redirected lytic assays.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens, Differentiation, T-Lymphocyte / immunology*
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CD3 Complex
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CD4-Positive T-Lymphocytes / immunology*
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Cell Death / immunology
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Clone Cells
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Cyclosporine / pharmacology
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Cytotoxicity Tests, Immunologic
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Interferon-gamma / physiology
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Interleukin-2 / metabolism
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Interleukin-4 / metabolism
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Mice
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Mice, Inbred DBA
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Receptors, Antigen, T-Cell / immunology*
Substances
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Antigens, Differentiation, T-Lymphocyte
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CD3 Complex
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Interleukin-2
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Receptors, Antigen, T-Cell
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Interleukin-4
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Interferon-gamma
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Cyclosporine