Genetic heterogeneity of early-onset familial breast cancer

H Sobol; S Mazoyer; S A Narod; S A Smith; D M Black; P Kerbrat; B Jamot; E Solomon; B A Ponder; D Guerin

doi:10.1007/BF00194307

Genetic heterogeneity of early-onset familial breast cancer

Hum Genet. 1992 Jun;89(4):381-3. doi: 10.1007/BF00194307.

Authors

H Sobol¹, S Mazoyer, S A Narod, S A Smith, D M Black, P Kerbrat, B Jamot, E Solomon, B A Ponder, D Guerin

Affiliation

¹ Oncology-Genetics Unit, Centre Léon Bérard, Lyon, France.

PMID: 1352270
DOI: 10.1007/BF00194307

Abstract

A gene for early-onset familial breast cancer has recently been mapped to the chromosome 17q12-23 region. In order to confirm the gene location, we have tested an extensive early-onset breast cancer family with 4 markers in this chromosome region. Linkage was negative with all 4 markers. This study suggests that there is genetic heterogeneity among early-onset breast cancer families.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Blotting, Southern
Breast Neoplasms / genetics*
Chromosomes, Human, Pair 17*
Female
Genetic Markers / genetics
Humans
Lod Score
Male
Molecular Sequence Data
Pedigree
Polymorphism, Restriction Fragment Length*

Substances

Genetic Markers