Metabotropic receptor mediated afterdepolarization in neocortical neurons

Eur J Pharmacol. 1992 Jul 1;226(3):279-80. doi: 10.1016/0922-4106(92)90073-5.

Abstract

In rat neocortical slices activation of glutamate metabotropic receptors with glutamate, quisqualate and 1S,3R-ACPD caused a spike-evoked afterdepolarization which replaced the normal afterhyperpolarization. In some neocortical neurons the afterdepolarization reached action potential threshold causing prolonged self-sustained firing. These effects of metabotropic receptor activation were similar to the action of muscarinic agonists in the same preparation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism*
  • Cycloleucine / analogs & derivatives
  • Cycloleucine / pharmacology
  • Glutamates / pharmacology
  • Glutamic Acid
  • In Vitro Techniques
  • Microelectrodes
  • Neuromuscular Depolarizing Agents / pharmacology
  • Neurons / drug effects
  • Neurons / metabolism*
  • Quisqualic Acid / pharmacology
  • Rats
  • Receptors, Glutamate / drug effects
  • Receptors, Glutamate / metabolism*

Substances

  • Glutamates
  • Neuromuscular Depolarizing Agents
  • Receptors, Glutamate
  • Cycloleucine
  • 1-amino-1,3-dicarboxycyclopentane
  • Glutamic Acid
  • Quisqualic Acid