Lignans from Saururus chinensis inhibiting the transcription factor NF-kappaB

Phytochemistry. 2003 Oct;64(3):765-71. doi: 10.1016/s0031-9422(03)00391-1.

Abstract

The sesquineolignans, saucerneol D and saucerneol E were isolated from the roots of Saururus chinensis together with four known lignans, manassantin A, manassantin B, (-)-saucerneol methyl ether, and (+)-saucernetin. Structure elucidation was based on the analysis of spectroscopic data and anti-inflammatory activity was studied using HeLa cells transfected with NF-kappaB reporter construct. All compounds except for (+)-saucernetin inhibited NF-kappaB dependent reporter gene expression with IC50 values of 2.5-16.9 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Gene Expression Regulation / drug effects
  • Genes, Reporter / drug effects
  • Genes, Reporter / genetics
  • HeLa Cells
  • Humans
  • Lignans / chemistry
  • Lignans / isolation & purification*
  • Lignans / pharmacology*
  • Luciferases / genetics
  • NF-kappa B / antagonists & inhibitors*
  • NF-kappa B / genetics
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry
  • Saururaceae / chemistry*
  • Stereoisomerism
  • Transfection

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Lignans
  • NF-kappa B
  • Luciferases