2-aryl-3-phenylamino-4,5-dihydro-2h-benz[g]indazoles with analgesic activity

Farmaco. 2003 Sep;58(9):845-9. doi: 10.1016/S0014-827X(03)00142-3.

Abstract

A series of 2-aryl-3-phenylamino-4,5-dihydro-2H-benz[g]indazoles was synthesized and tested for antiarrhythmic, local anaesthetic and analgesic activity. The title compounds showed a good antinociceptive activity.

Publication types

  • Comparative Study

MeSH terms

  • Analgesics / chemical synthesis
  • Analgesics / pharmacology*
  • Anesthetics, Local / chemical synthesis
  • Anesthetics, Local / pharmacology
  • Aniline Compounds / chemical synthesis
  • Aniline Compounds / pharmacology*
  • Animals
  • Anti-Arrhythmia Agents / chemical synthesis
  • Anti-Arrhythmia Agents / pharmacology
  • Crystallization
  • Drug Compounding
  • Female
  • Indazoles / chemical synthesis
  • Indazoles / pharmacology*
  • Injections, Intraperitoneal
  • Male
  • Mice
  • Pain Measurement
  • Rats
  • Structure-Activity Relationship
  • Transition Temperature
  • Ventricular Fibrillation / drug therapy

Substances

  • Analgesics
  • Anesthetics, Local
  • Aniline Compounds
  • Anti-Arrhythmia Agents
  • Indazoles