Spinal MRI of vincristine neuropathy mimicking Guillain-Barré syndrome

Pediatr Radiol. 2003 Nov;33(11):791-3. doi: 10.1007/s00247-002-0849-6. Epub 2003 Sep 13.

Abstract

A 4.3-year-old girl with acute leukaemia, who was being treated with chemotherapy (including vincristine), developed paraplegia. Spinal MRI showed diffusely enhancing nerve roots on contrast-enhanced images. Spinal fluid analysis showed a normal protein level. Vincristine neuropathy mimicking Guillain-Barré syndrome is thought to be the cause of the MRI abnormalities.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols
  • Child, Preschool
  • Diagnosis, Differential
  • Female
  • Guillain-Barre Syndrome / diagnosis*
  • Humans
  • Magnetic Resonance Imaging*
  • Paraplegia / chemically induced*
  • Paraplegia / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Spinal Nerve Roots / pathology
  • Spine / pathology*
  • Vincristine / administration & dosage
  • Vincristine / adverse effects*

Substances

  • Vincristine