Generation of a subtype-specific neutralization epitope in foot-and-mouth disease virus of a different subtype

J Gen Virol. 1992 Jan:73 ( Pt 1):213-6. doi: 10.1099/0022-1317-73-1-213.

Abstract

An epitope involved in neutralization of foot-and-mouth disease virus (FMDV) of subtype C3 was generated by a single amino acid replacement in VP1 of FMDV of subtype C1. The replacement [Ser (139)----Ile, in the immunodominant site A] was consistently found in those FMDV C1 Santa Pau-Sp/70 mutants resistant to neutralization by monoclonal antibody (MAb) SD6 (specific for most C1 viruses) that acquired the capacity to be neutralized by MAb 7AB5 (specific for C3 viruses).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antibodies, Monoclonal
  • Antigens, Viral / chemistry
  • Antigens, Viral / immunology*
  • Aphthovirus / chemistry
  • Aphthovirus / immunology*
  • Epitopes / chemistry
  • Epitopes / immunology*
  • Molecular Sequence Data
  • Mutation
  • Neutralization Tests
  • Viral Plaque Assay

Substances

  • Antibodies, Monoclonal
  • Antigens, Viral
  • Epitopes