The Authors consider the quantity of CEA-AFP-MCA-CA 125 measurements performed by their laboratory during ten months in 1989-90: 1.000 for CEA, 500 for AFP, 52 for MCA, 36 for CA 125. The observation of scarce significance (especially for CEA and AFP) has, in this case, only a statistical sense, depending on the unknown motivation of the analysis requests. They also observe greater significance of MCA and CA 125 measurements, and they underline the necessity to correlate requests, clinical situations and results, according on their peculiar purpose: to verify the reliability of the demands in order to value the validity of the markers, avoiding useless and not specific data for a better monitoring of the neoplastic patient.