12-O-tetradecanoylphorbol 13-acetate induced differentiation in human lung squamous carcinoma cells

G J Rabiasz; S P Langdon; L Anderson; A A Ritchie; W R Miller; J F Smyth

doi:10.1038/bjc.1992.293

12-O-tetradecanoylphorbol 13-acetate induced differentiation in human lung squamous carcinoma cells

Br J Cancer. 1992 Sep;66(3):439-43. doi: 10.1038/bjc.1992.293.

Authors

G J Rabiasz¹, S P Langdon, L Anderson, A A Ritchie, W R Miller, J F Smyth

Affiliation

¹ ICRF Medical Oncology Unit, Western General Hospital, Edinburgh, UK.

Abstract

Three human lung squamous carcinoma cell lines (NX002, CX140 and CX143) demonstrate features of squamous differentiation including involucrin synthesis and competence to form cornified envelopes. 12-O-Tetradecanoylphorbol 13-acetate inhibits growth of these cell lines and this growth inhibition is associated with enhanced differentiation.

MeSH terms

Antigens, Neoplasm / analysis
Carcinoma, Squamous Cell / chemistry
Carcinoma, Squamous Cell / immunology
Carcinoma, Squamous Cell / pathology*
Cell Differentiation / drug effects*
Cell Division / drug effects
Humans
Keratins / analysis
Lung Neoplasms / chemistry
Lung Neoplasms / immunology
Lung Neoplasms / pathology*
Protein Precursors / analysis*
Tetradecanoylphorbol Acetate / pharmacology*
Tumor Cells, Cultured

Substances

Antigens, Neoplasm
Protein Precursors
involucrin
Keratins
Tetradecanoylphorbol Acetate