Nodular sclerosing Hodgkin's disease and large cell lymphoma. Immunophenotypic characterization of a composite case

Virchows Arch A Pathol Anat Histopathol. 1992;421(3):271-5. doi: 10.1007/BF01611185.

Abstract

Composite lymphomas have rarely been reported in Hodgkin's disease (HD), except in the lymphocyte predominance sub-type, and immunohistochemical investigations have been performed in only few cases. We describe the histological and immunophenotypical findings in a case of composite nodular sclerosing HD and high-grade, large cell non-Hodgkin's lymphoma (NHL). In our case HD and NHL cells displayed striking morphological and immunophenotypical divergence, suggesting a lack of correlation between the two neoplasms.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigens, CD / analysis
  • Antigens, CD20
  • Antigens, Differentiation, B-Lymphocyte / analysis
  • Antineoplastic Agents / administration & dosage
  • HLA-DR Antigens / analysis
  • Histocompatibility Antigens Class II / analysis
  • Hodgkin Disease / pathology*
  • Humans
  • Lewis X Antigen
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Lymphoma, Non-Hodgkin / pathology*
  • Male
  • Membrane Glycoproteins / analysis
  • Mucin-1
  • Neoplasms, Multiple Primary / pathology*
  • Phenotype
  • Sialyltransferases / analysis
  • beta-D-Galactoside alpha 2-6-Sialyltransferase

Substances

  • Antigens, CD
  • Antigens, CD20
  • Antigens, Differentiation, B-Lymphocyte
  • Antineoplastic Agents
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II
  • Lewis X Antigen
  • Membrane Glycoproteins
  • Mucin-1
  • invariant chain
  • Sialyltransferases
  • beta-D-Galactoside alpha 2-6-Sialyltransferase