Impaired iron status in rats as induced by copper deficiency

Biol Trace Elem Res. 1992 Oct;35(1):77-9. doi: 10.1007/BF02786240.

Abstract

The hypothesis was tested that marginal copper deficiency affects iron status. Copper restriction (1 vs 5 mg Cu/kg diet) significantly lowered iron concentrations and transferrin saturation in plasma and reduced blood hemoglobin, hematocrit, and iron concentrations in tibia and femur, but raised iron concentrations in liver. Marginal copper deficiency did not affect feed intake and bodyweight gain.

MeSH terms

  • Animals
  • Body Weight
  • Copper / deficiency*
  • Eating
  • Femur / chemistry
  • Hematocrit
  • Hemoglobins / analysis
  • Iron / blood
  • Iron / metabolism*
  • Liver / chemistry
  • Male
  • Nutritional Status
  • Rats
  • Rats, Wistar
  • Tibia / chemistry
  • Transferrin / metabolism

Substances

  • Hemoglobins
  • Transferrin
  • Copper
  • Iron