Ti gamma A + delta TCS1+ T cells in human thymus. Analysis of the T cell receptor

Eur J Immunol. 1992 Jul;22(7):1947-50. doi: 10.1002/eji.1830220742.

Abstract

TcR1+ T cells in peripheral blood have been shown to express in an exclusive fashion either the Ti gamma A or the delta TCS1 epitope. Here, we characterize a subset of TcR1+ T cells in fresh thymus co-expressing the Ti gamma A and delta TCS1 epitopes. TcR1dim and TcR1bright clones can be distinguished. Biochemical and molecular studies on both types of clones generated from these thymocytes reveal a unique T cell receptor structure characterized by the use of a V gamma 9/C gamma 2-encoded 55-kDa gamma chain nondisulfide linked to a V delta 1-encoded delta chain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Disulfides / analysis
  • Humans
  • Receptors, Antigen, T-Cell, gamma-delta / analysis*
  • T-Lymphocyte Subsets / immunology*
  • Thymus Gland / immunology*

Substances

  • Disulfides
  • Receptors, Antigen, T-Cell, gamma-delta