Molecular characterization of regulatory elements controlling expression of the Bacillus subtilis recA+ gene

Biochimie. 1992 Jul-Aug;74(7-8):755-62. doi: 10.1016/0300-9084(92)90148-8.

Abstract

Expression of the Bacillus subtilis recA gene is induced following DNA damage as well as during the development of the competent state. DNA damage-induction of the recA gene occurs by a RecA-dependent mechanism, whereas competence-induction occurs by a RecA-independent mechanism. To examine the molecular mechanisms that control the expression of the recA gene, a deletion analysis of the recA promoter region was performed. A regulatory region that is required for repression of recA expression was identified upstream of the recA promoter. Deletion of this regulatory region derepressed expression and abolished damage-induction of the recA promoter. Within this region are sequences similar to the consensus sequence that has been identified within DNA damage-inducible promoter regions of other B subtilis genes. Another regulatory region was identified that is required for the RecA-independent, competence-specific induction of the recA gene. Deletion of these sequences significantly reduced competence-induction of the recA promoter.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Bacillus subtilis / genetics*
  • Base Sequence
  • DNA Damage / genetics
  • Gene Expression Regulation, Bacterial*
  • Genes, Bacterial
  • Molecular Sequence Data
  • Mutation
  • Plasmids
  • Promoter Regions, Genetic
  • Rec A Recombinases / genetics*
  • Recombination, Genetic
  • Regulatory Sequences, Nucleic Acid*
  • Transcription, Genetic
  • Transformation, Bacterial

Substances

  • Rec A Recombinases

Associated data

  • GENBANK/M91429
  • GENBANK/M91430
  • GENBANK/M93298
  • GENBANK/M93299
  • GENBANK/M93300
  • GENBANK/M93301
  • GENBANK/X52132
  • GENBANK/X64259
  • GENBANK/X72068
  • GENBANK/X72069