Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2. Taxonomy, fermentation, isolation, structure determination and biological properties

K Hamano; M Kinoshita-Okami; A Hemmi; A Sato; M Hisamoto; K Matsuda; K Yoda; H Haruyama; T Hosoya; K Tanzawa

doi:10.7164/antibiotics.45.1195

Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2. Taxonomy, fermentation, isolation, structure determination and biological properties

J Antibiot (Tokyo). 1992 Aug;45(8):1195-201. doi: 10.7164/antibiotics.45.1195.

Authors

K Hamano¹, M Kinoshita-Okami, A Hemmi, A Sato, M Hisamoto, K Matsuda, K Yoda, H Haruyama, T Hosoya, K Tanzawa

Affiliation

¹ Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.

PMID: 1399838
DOI: 10.7164/antibiotics.45.1195

Abstract

A new inhibitor of phospholipase A2 was isolated from the fermentation broth of Aspergillus unguis. The structure, with a depsidone carbon skeleton, was assigned by spectroscopic experiments.

MeSH terms

Animals
Aspergillus / classification*
Aspergillus / metabolism
Fermentation
Lactones / isolation & purification*
Lactones / pharmacology
Nitrendipine / metabolism
Phospholipases A / antagonists & inhibitors*
Phospholipases A2
Swine

Substances

Lactones
folipastatin
Nitrendipine
Phospholipases A
Phospholipases A2