Comparative study between 4-aminobutyrate-2-oxoglutarate aminotransferase (GABA-T) from rat forebrain and cerebellum

C Arce; S Cañadas; M De Vicente; M J Oset-Gasque; M P González

doi:10.1007/BF00968009

Comparative study between 4-aminobutyrate-2-oxoglutarate aminotransferase (GABA-T) from rat forebrain and cerebellum

Neurochem Res. 1992 Jul;17(7):703-6. doi: 10.1007/BF00968009.

Authors

C Arce¹, S Cañadas, M De Vicente, M J Oset-Gasque, M P González

Affiliation

¹ Instituto de Bioquimica (Centro mixto C.S.I.C.-U.C.M.), Facultad de Farmacia, Ciudad Universitaria, Madrid, Spain.

PMID: 1407267
DOI: 10.1007/BF00968009

Abstract

In this study differences in the biochemical properties of 4-aminobutyric acid aminotransferase (GABA-T) from forebrain and cerebellum were detected. These differences may be related to: a) the characteristics of the catalytic site, b) the substrate affinities and c) their pyridoxal-phosphate requirements which suggests that PLP could be a physiological regulator of these forms of brain GABA-T.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

4-Aminobutyrate Transaminase / metabolism*
Aminooxyacetic Acid / pharmacology
Animals
Aspartic Acid / pharmacology
Brain Chemistry
Cerebellum / enzymology*
Prosencephalon / enzymology*
Pyridoxal Phosphate / pharmacology
Rats
Rats, Wistar
gamma-Aminobutyric Acid / metabolism

Substances

Aminooxyacetic Acid
Aspartic Acid
gamma-Aminobutyric Acid
Pyridoxal Phosphate
4-Aminobutyrate Transaminase