Antineutrophil cytoplasmic autoantibody-associated vasculitis presenting as Sjögren's syndrome

Arthritis Rheum. 1992 Nov;35(11):1373-6. doi: 10.1002/art.1780351120.

Abstract

A 63-year-old woman, in whom a diagnosis of Sjögren's syndrome was initially made, proved to have systemic vasculitis with salivary gland involvement and necrotizing and crescentic glomerulonephritis. Antineutrophil cytoplasmic autoantibodies (ANCA) against myeloperoxidase were positive. ANCA-associated vasculitis should be considered in the differential diagnosis of Sjögren's syndrome. A positive finding on immunoassay for ANCA against myeloperoxidase or proteinase 3 may help establish the diagnosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies / analysis*
  • Biopsy
  • Diagnosis, Differential
  • Female
  • Granulomatosis with Polyangiitis / complications
  • Granulomatosis with Polyangiitis / diagnosis
  • Humans
  • Middle Aged
  • Salivary Gland Diseases / diagnosis
  • Salivary Gland Diseases / etiology
  • Sjogren's Syndrome / diagnosis*
  • Submandibular Gland / pathology
  • Vasculitis / diagnosis*
  • Vasculitis / immunology

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies