Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia

Brain Res Mol Brain Res. 2003 Sep 10;117(1):104-7. doi: 10.1016/s0169-328x(03)00327-9.

Abstract

To investigate the role of methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, we analyzed the genotypes of MTHFR677 and MTHFR1298 of 130 schizophrenic patients and 226 controls, using a polymerase chain reaction restriction fragment length polymorphism method. The MTHFR T677 allele was significantly distributed (chi(2)=7.900; P=0.019), between schizophrenic cases and healthy controls. The T677T genotype was overrepresented in the schizophrenic patients (OR=2.504; 95% CI=1.276-4.915; chi(2)=7.477; P=0.006). The T677T/A1298A, and C677T/C1298C compound genotypes were greater in the schizophrenic patients (OR=3.157; 95% CI=1.522-6.545; chi(2)=10.336; P=0.001 and OR=1.744; 95% CI=0.108-28.121; chi(2)=0.158; P=0.691, respectively). The MTHFR T677 allele and T677T and T677T/A1298A genotypes are genetic risk factors for schizophrenia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine / genetics
  • Alleles
  • Chi-Square Distribution
  • Cysteine / genetics
  • DNA Mutational Analysis
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Lymphocytes / metabolism
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
  • Point Mutation
  • Polymerase Chain Reaction / methods
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length
  • Schizophrenia / blood
  • Schizophrenia / genetics*
  • Threonine / genetics

Substances

  • Threonine
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Cysteine
  • Alanine

Associated data

  • OMIM/181500