Abstract
We have developed an automated system for the preparation of highly concentrated 188Re-perrhenate, diethylenetriamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG3). The three procedural steps include concentration of 188Re-perrhanerate, chelation and purification and sterilization. The steps are operated by a small micro-controller. The eluted 188Re-perrhenate of 15 GBq/18 ml from 37 GBq 188W/188Re-generator was concentrated to 1.2 ml in 10 +/- 0.5 min with a recovery yield of 95 +/- 1.5%. We obtained the highest radiochemical yield of 95.4 +/- 2.8% and 98.5 +/- 1.2% for 188Re-DTPA and MAG3 at the oil bath temperatures of 95-97 degrees C and 93-97 degrees C, respectively.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
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Validation Study
MeSH terms
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Brachytherapy / instrumentation
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Brachytherapy / methods
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Computer Systems
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Computing Methodologies
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Coronary Restenosis / prevention & control
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Coronary Restenosis / radiotherapy
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Equipment Design
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Equipment Failure Analysis
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Glycine / analogs & derivatives*
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Glycine / chemical synthesis
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Glycine / chemistry*
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Glycine / isolation & purification
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Humans
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Isotope Labeling / instrumentation*
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Isotope Labeling / methods
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Pentetic Acid / chemical synthesis
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Pentetic Acid / chemistry*
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Pentetic Acid / isolation & purification
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Radioisotopes / chemistry*
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Radioisotopes / isolation & purification
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Radiopharmaceuticals / chemical synthesis*
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Radiopharmaceuticals / chemistry
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Radiopharmaceuticals / isolation & purification
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Rhenium / chemistry*
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Rhenium / isolation & purification
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Robotics / instrumentation*
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Robotics / methods
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Systems Integration
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Vascular Diseases / prevention & control
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Vascular Diseases / radiotherapy
Substances
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Radioisotopes
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Radiopharmaceuticals
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perrhenate
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N-(mercaptoacetyl)glycine
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Rhenium
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Pentetic Acid
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Glycine