Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-adenosylhomocysteine hydrolase

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):589-92. doi: 10.1081/NCN-120021961.

Abstract

Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / analogs & derivatives
  • Adenosine / chemical synthesis*
  • Adenosine / chemistry
  • Adenosine / pharmacology
  • Adenosylhomocysteinase / adverse effects*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Indicators and Reagents
  • Kinetics
  • Models, Molecular
  • Molecular Conformation

Substances

  • Enzyme Inhibitors
  • Indicators and Reagents
  • neplanocin A
  • Adenosylhomocysteinase
  • Adenosine