Nuclease stability of LNA oligonucleotides and LNA-DNA chimeras

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1041-3. doi: 10.1081/NCN-120022731.

Abstract

The stabilizing properties of LNA and alpha-L-LNA oligonucleotides against endo- and 3'-exonucleases have been evaluated.

MeSH terms

  • DNA / chemistry*
  • Drug Stability
  • Endoribonucleases / metabolism
  • Exonucleases / metabolism*
  • Oligodeoxyribonucleotides / chemistry
  • Oligonucleotides
  • Oligonucleotides, Antisense / chemistry*
  • Phosphodiesterase I
  • Substrate Specificity

Substances

  • Oligodeoxyribonucleotides
  • Oligonucleotides
  • Oligonucleotides, Antisense
  • locked nucleic acid
  • oligo (dT)
  • DNA
  • Endoribonucleases
  • Exonucleases
  • spleen exonuclease
  • Phosphodiesterase I
  • phosphodiesterase I, snake venom