Abstract
Upon feeding of [2-(13)C,4-(2)H]-1-deoxy-D-xylulose to Streptomyces ghanaensis, the deuterium label was retained exclusively at positions C-7 and C-17 in the moenocinol part of the moenomycin antibiotics. This result vindicates the hypothesis that the C(25) structure of moenocinol is assembled from a C(10) and a C(15) precursor, each of which requires for its formation the involvement of a dimethylallyl diphosphate starter unit.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / biosynthesis*
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Anti-Bacterial Agents / chemistry
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Hemiterpenes / chemistry
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Oligosaccharides / biosynthesis*
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Oligosaccharides / chemistry
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Organophosphorus Compounds / chemistry
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Streptomyces / metabolism*
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Terpenes / blood*
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Terpenes / chemistry
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Xylulose / analogs & derivatives*
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Xylulose / metabolism
Substances
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Anti-Bacterial Agents
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Hemiterpenes
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Oligosaccharides
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Organophosphorus Compounds
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Terpenes
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moenocinol
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isopentenyl pyrophosphate
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3,3-dimethylallyl pyrophosphate
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Xylulose
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1-deoxy-2-pentulose
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moenomycin