Peptide derivatives of antibiotics tylosin and desmycosin, protein synthesis inhibitors

N V Sumbatyan; G A Korshunova; A A Bogdanov

doi:10.1023/a:1026318914546

Peptide derivatives of antibiotics tylosin and desmycosin, protein synthesis inhibitors

Biochemistry (Mosc). 2003 Oct;68(10):1156-8. doi: 10.1023/a:1026318914546.

Authors

N V Sumbatyan¹, G A Korshunova, A A Bogdanov

Affiliation

¹ Faculty of Chemistry, Lomonosov Moscow State University, Moscow, 119992, Russia.

PMID: 14616087
DOI: 10.1023/a:1026318914546

Abstract

Biologically active peptide derivatives of 16-member macrolide antibiotics were synthesized as potential probes for the investigation of nascent peptide chain topography in the ribosomal exit tunnel. The tylosin and desmycosin aldehyde groups at the C6 position of the lactone ring were modified by the aminooxyacetyl-L-alanyl-L-alanine methyl ester.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry*
Peptides / chemistry*
Protein Biosynthesis
Protein Synthesis Inhibitors / chemical synthesis*
Protein Synthesis Inhibitors / chemistry*
Tylosin / analogs & derivatives*
Tylosin / chemical synthesis*
Tylosin / chemistry

Substances

Anti-Bacterial Agents
Peptides
Protein Synthesis Inhibitors
Tylosin