Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones

Bioorg Med Chem Lett. 2003 Dec 1;13(23):4173-7. doi: 10.1016/j.bmcl.2003.08.031.

Abstract

A novel series of oxazolidinones containing a pyrroloaryl substituent was synthesized and screened against a representative panel of susceptible and resistant Gram-positive bacteria. Several members of this series were found to have antibacterial activity comparable to or better than linezolid.

Publication types

  • Comparative Study

MeSH terms

  • Acetamides / chemical synthesis*
  • Acetamides / chemistry
  • Acetamides / pharmacology*
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Gram-Positive Bacteria / drug effects*
  • Linezolid
  • Microbial Sensitivity Tests
  • Oxazolidinones / chemical synthesis*
  • Oxazolidinones / chemistry
  • Oxazolidinones / pharmacology*
  • Structure-Activity Relationship

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Linezolid