Design of a cyclic peptide that targets a viral RNA

J Am Chem Soc. 2003 Dec 24;125(51):15704-5. doi: 10.1021/ja036344h.

Abstract

The Tat protein controls transcription in lentiviruses such as HIV. A cyclic peptide analog of the RNA binding domain of the bovine immunodeficiency virus (BIV) Tat protein is shown to bind specifically to its target RNA stem loop. NMR data indicate a similar mode of binding of linear and cyclic peptides.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cattle
  • Drug Design
  • Gene Products, tat / chemistry*
  • Gene Products, tat / metabolism
  • Gene Products, tat / pharmacology
  • Immunodeficiency Virus, Bovine / chemistry
  • Immunodeficiency Virus, Bovine / genetics*
  • Immunodeficiency Virus, Bovine / metabolism
  • Nuclear Magnetic Resonance, Biomolecular
  • Peptide Fragments / chemistry
  • Peptide Fragments / metabolism*
  • Peptide Fragments / pharmacology
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / metabolism*
  • Peptides, Cyclic / pharmacology
  • Protein Conformation
  • RNA, Viral / drug effects
  • RNA, Viral / metabolism*
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / metabolism*
  • RNA-Binding Proteins / pharmacology
  • Substrate Specificity

Substances

  • Gene Products, tat
  • Peptide Fragments
  • Peptides, Cyclic
  • RNA, Viral
  • RNA-Binding Proteins