Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats

Ann N Y Acad Sci. 2003 Nov:1003:415-8. doi: 10.1196/annals.1300.040.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / physiology*
  • Cocaine / pharmacology*
  • Cocaine-Related Disorders / psychology*
  • Dose-Response Relationship, Drug
  • Nicotine / pharmacology*
  • Nicotinic Agonists / pharmacology*
  • Pyridines / pharmacology*
  • Rats
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors*
  • Reward
  • Tobacco Use Disorder / psychology*

Substances

  • Nicotinic Agonists
  • Pyridines
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate
  • Nicotine
  • 6-methyl-2-(phenylethynyl)pyridine
  • Cocaine