The aim of the project was to create a computer program--expert system, which will support a doctor when a management for patients with acute coronary syndrome needs to be chosen. The expert system consists of four modules: knowledge base, previous cases database, inference engine and explanation module. Knowledge base was created with support of clinical experts, based on current management standards, guidelines and results of clinical trials according to evidence-based medicine rules. Data from new patient are added to the case database. Inference engine integrates two types of reasoning rule-based and case-based reasoning. Computer expert system gives unambiguous and objective answer. Recommendation given by an expert system can be reliable. At present the system is tested in clinical practice. Strategies recommended by the system are compared to the management applied in patients treated in Cardiology Clinic.