Abstract
Nematodes were found to synthesize phosphorylcholine-containing molecules not present in higher organisms, i.e. phosphorylcholine-substituted glycosphingolipids and (glyco)proteins. Investigations on the biosynthesis of these structures provided first biochemical evidence for the presence of the Kennedy and Bremer-Greenberg pathways in the model organism Caenorhabditis elegans.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Caenorhabditis elegans / metabolism*
-
Carbon Radioisotopes
-
Diacylglycerol Cholinephosphotransferase / antagonists & inhibitors
-
Electrophoresis, Polyacrylamide Gel
-
Farnesol / pharmacology
-
Glycoproteins / biosynthesis*
-
Glycosphingolipids / biosynthesis*
-
Phosphorylcholine / metabolism*
Substances
-
Carbon Radioisotopes
-
Glycoproteins
-
Glycosphingolipids
-
Phosphorylcholine
-
Farnesol
-
Diacylglycerol Cholinephosphotransferase