Interferon with ribavirin therapy has been proposed for the treatment of hepatitis C recurring in liver transplants.
Aim of the study: Was to assess the efficacy of standard combination therapy (interferon plus ribavirin) of chronic hepatitis C in transplanted patients with recurrent severe HCV induced chronic hepatitis.
Methods: 12 patients with HCV-PCR positive reaction (genotype 1b) were treated with the therapy of interferon-alpha-2b (3 MU three times a week) and 800-1000 mg ribavirin daily. Liver biopsy had been done in every patients before and after the treatment. Study endpoints were the end of treatment and the 6 month post-therapy sustained virologic response.
Results: At the end of treatment 3 patients were negative for HCV-PCR and all of them had negative reaction after 6 month follow-up period.
Conclusion: The results are in a good accordance with treatment of patients with chronic hepatitis C without liver transplantation.